Gene Variant Detail

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Gene RET
Variant S767R
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET S767R lies within the protein kinase domain of the Ret protein (UniProt.org). S767R results in decreased Ret, Erk, and Stat3 phosphorylation, reduced cell migration and colony formation compared to wild-type Ret protein in culture (PMID: 11438491, PMID: 22837065).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET S767R

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Transcript NM_020975.6
gDNA chr10:g.43118389T>G
cDNA c.2301T>G
Protein p.S767R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_020630 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_020975 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43126596_43126597delTCinsCG c.2299_2300delTCinsCG p.S767R RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38
NM_001406782.1 chr10:g.43126731_43126732delTCinsCG c.2299_2300delTCinsCG p.S767R RefSeq GRCh38/hg38
NM_001355216.1 chr10:g.43126596_43126597delTCinsCG c.2299_2300delTCinsCG p.S767R RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118389T>G c.2301T>G p.S767R RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries