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Gene RET
Variant P1039L
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions RET P1039L lies within the cytoplasmic domain of the Ret protein (UniProt.org). P1039L results in a loss of response to GDNF-regulated apoptosis (PMID: 10921886), and therefore, is predicted to lead to a loss of Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET P1039L

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Transcript NM_020975.6
gDNA chr10:g.43126651C>T
cDNA c.3116C>T
Protein p.P1039L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_020975 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43126651C>T c.3116C>T p.P1039L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References