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Gene RET
Variant P973L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET P973L lies within the protein kinase domain of the Ret protein (UniProt.org). P973L results in decreased Ret mRNA and protein levels and retains the ability to phosphorylate ERK in the presence of ligand in culture (PMID: 11438491), but has not been fully biochemically characterized and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET P973L

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Transcript NM_020975.6
gDNA chr10:g.43123787C>T
cDNA c.2918C>T
Protein p.P973L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.6 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_020975 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38
NM_020630 chr10:g.43123787C>T c.2918C>T p.P973L RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References