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Gene RET
Variant A1105V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions RET A1105V lies within the cytoplasmic domain of the Ret protein (UniProt.org). A1105V results in GDNF-dependent Mapk activation to a similar level as wild-type Ret in culture (PMID: 22729463), and therefore, is predicted to have no effect on Ret protein function.
Associated Drug Resistance
Category Variants Paths

RET mutant RET A1105V

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Transcript NM_020975.6
gDNA chr10:g.43128238C>T
cDNA c.3314C>T
Protein p.A1105V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406743.1 chr10:g.43128238C>T c.3314C>T p.A1105V RefSeq GRCh38/hg38
NM_020975 chr10:g.43128238C>T c.3314C>T p.A1105V RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43128238C>T c.3314C>T p.A1105V RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43128238C>T c.3314C>T p.A1105V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References