Gene Variant Detail

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Gene RET
Variant K758M
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET K758M lies within the protein kinase domain of the Ret protein (UniProt.org). K758M results in a loss of phosphorylation of Ret and downstream signaling molecules including Erk1/2 and Stat3, decreased colony formation and response to GDNF-regulated apoptosis compared to wild-type Ret protein in culture (PMID: 22837065).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET K758M

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Transcript NM_020975.6
gDNA chr10:g.43116720A>T
cDNA c.2273A>T
Protein p.K758M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_020630 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43116720A>T c.2273A>T p.K758M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References