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Gene RET
Variant E734K
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET E734K lies within the protein kinase domain of the Ret protein (UniProt.org). E734K results in a loss of phosphorylation of Ret and downstream signaling molecules including Erk1/2 and Stat3, decreased migration, colony formation, and response to GDNF-regulated apoptosis compared to wild-type Ret protein in culture (PMID: 22837065).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET E734K

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Transcript NM_020975.6
gDNA chr10:g.43116647G>A
cDNA c.2200G>A
Protein p.E734K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_020975 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_020630 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43116647G>A c.2200G>A p.E734K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References