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Gene RET
Variant D771N
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET D771N lies within the protein kinase domain of the Ret protein (UniProt.org). D771N results in decreased phosphorylation of Ret and downstream signaling molecules including Erk1/2 and Stat3, decreased migration, colony formation, and response to GDNF-regulated apoptosis compared to wild-type Ret protein in culture (PMID: 22837065).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET D771N

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Transcript NM_020975.6
gDNA chr10:g.43118399G>A
cDNA c.2311G>A
Protein p.D771N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001406783.1 chr10:g.43128261G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43120180G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43120180G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_020975 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001355216.2 chr10:g.43126608G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_001355216.1 chr10:g.43126608G>A c.2311G>A p.D771N RefSeq GRCh38/hg38
NM_020630 chr10:g.43118399G>A c.2311G>A p.D771N RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References