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Gene RET
Variant R912Q
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RET R912Q lies within the protein kinase domain of the Ret protein (UniProt.org). R912Q results in decreased phosphorylation of Ret and Erk1/2, decreased migration and colony formation compared to wild-type Ret protein in culture (PMID: 22837065).
Associated Drug Resistance
Category Variants Paths

RET mutant RET inact mut RET R912Q

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Transcript NM_020975.6
gDNA chr10:g.43121950G>A
cDNA c.2735G>A
Protein p.R912Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_020975 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_020630 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43121950G>A c.2735G>A p.R912Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
RET R912Q loss of function