NTRK1 G667S
Gene Variant Detail

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Gene NTRK1
Variant G667S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NTRK1 G667S lies within the protein kinase domain of the Ntrk1 protein (UniProt.org). G667S has been associated with kinase inhibitor resistance in the context of NTRK1 fusions (PMID: 29466156, PMID: 33328556, PMID: 34790577), but has not been biochemically characterized and therefore, its effect on Ntrk1 protein function is unknown (PubMed, Apr 2026).
Associated Drug Resistance Y
Category Variants Paths

NTRK1 mutant NTRK1 G667S

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Transcript NM_002529.4
gDNA chr1:g.156879315G>A
cDNA c.1999G>A
Protein p.G667S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002529 chr1:g.156879315G>A c.1999G>A p.G667S RefSeq GRCh38/hg38
NM_002529.4 chr1:g.156879315G>A c.1999G>A p.G667S RefSeq GRCh38/hg38
NM_002529.3 chr1:g.156879315G>A c.1999G>A p.G667S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
NTRK1 G667S unknown