NTRK1 F589L
Gene Variant Detail

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Gene NTRK1
Variant F589L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NTRK1 F589L lies within the protein kinase domain of the Ntrk1 protein (UniProt.org). F589L has been demonstrated to promote secondary drug resistance in the context of LMNA-NTRK1 (PMID: 29466156, PMID: 34625502) and TMP3-NTRK1 (PMID: 33328556), but has not been biochemically characterized and therefore, its effect on Ntrk1 protein function is unknown (PubMed, Feb 2026).
Associated Drug Resistance Y
Category Variants Paths

NTRK1 mutant NTRK1 F589L

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Transcript NM_002529.4
gDNA chr1:g.156876532T>C
cDNA c.1765T>C
Protein p.F589L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002529 chr1:g.156876532T>C c.1765T>C p.F589L RefSeq GRCh38/hg38
NM_002529.3 chr1:g.156876532T>C c.1765T>C p.F589L RefSeq GRCh38/hg38
NM_002529.4 chr1:g.156876532T>C c.1765T>C p.F589L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References