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Gene BRAF
Variant I463X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF I463X indicates any BRAF missense mutation that results in replacement of the isoleucine (I) at amino acid 463 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF I463X

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Transcript NM_004333.6
gDNA chr7:g.140781619_140781621
cDNA c.1387_1389
Protein p.I463
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378475.1 chr7:g.140776953_140776955 c.1387_1389 p.I463 RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781619_140781621 c.1387_1389 p.I463 RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781619_140781621 c.1387_1389 p.I463 RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781619_140781621 c.1387_1389 p.I463 RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781619_140781621 c.1387_1389 p.I463 RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781619_140781621 c.1387_1389 p.I463 RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781619_140781621 c.1387_1389 p.I463 RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781619_140781621 c.1387_1389 p.I463 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03839342 Phase II Binimetinib + Encorafenib Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations (BEAVER) Active, not recruiting CAN 0