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Gene BRAF
Variant E586X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF E586X indicates any BRAF missense mutation that results in replacement of the glutamic acid (E) at amino acid 586 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF E586X

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Transcript NM_004333.6
gDNA chr7:g.140753377_140753379
cDNA c.1756_1758
Protein p.E586
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.6 chr7:g.140753377_140753379 c.1756_1758 p.E586 RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140749410_140749412 c.1756_1758 p.E586 RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753377_140753379 c.1756_1758 p.E586 RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753377_140753379 c.1756_1758 p.E586 RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753377_140753379 c.1756_1758 p.E586 RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753377_140753379 c.1756_1758 p.E586 RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753377_140753379 c.1756_1758 p.E586 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References