Gene Variant Detail

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Gene BRAF
Variant S465A
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF S465A lies within the protein kinase domain of the Braf protein (UniProt.org). S465A results in basal Mek phosphorylation and Mek phosphorylation upon Ras activation to similar levels as wild-type Braf in culture (PMID: 27034005), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF S465A

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Transcript NM_004333.6
gDNA chr7:g.140781615A>C
cDNA c.1393T>G
Protein p.S465A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781615A>C c.1393T>G p.S465A RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References