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Gene BRAF
Variant S465D
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF S465D lies within the protein kinase domain of the Braf protein (UniProt.org). S465D results in basal Mek phosphorylation and Mek phosphorylation upon Ras activation to similar levels as wild-type Braf in culture (PMID: 27034005), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF S465D

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Transcript NM_004333.6
gDNA chr7:g.140781614_140781615delTCinsGA
cDNA c.1393_1394delTCinsGA
Protein p.S465D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.2 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781614_140781615delGAinsTC c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_004333 chr7:g.140781614_140781615delGAinsTC c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries