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Gene BRAF
Variant A81_M438del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF A81_M438del results in the deletion of 358 amino acids of the Braf protein from amino acids 81 to 438 (UniProt.org). A81_M438del (reported as internal deletion of exons 3-10) has not been characterized, however, due to the deletion of the CR1 autoinhibitory domain and preservation of the protein kinase domain (PMID: 23890088, PMID: 22113612, PMID: 29171936), is predicted to lead to a gain of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF A81_M438del

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Transcript NM_004333.6
gDNA chr7:g.140783022_140834873del51852
cDNA c.242_1314+1del51852
Protein p.A81_M438del358
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378469.1 chr7:g.140781628_140834872del53245 c.241_1314del53245 p.A81_G438del358 RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
XM_017012558 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140783031_140834873del51843 c.241_1314del51843 p.A81_R438del358 RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140781658_140834716del53059 c.241_1314del53059 p.S81_W438del358 RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140778042_140834720del56679 c.241_1314del56679 p.S81_P438del358 RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140781592_140834770del53179 c.241_1314del53179 p.A81_Y438del358 RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
NM_004333 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140781585_140834874del53290 c.241_1314del53290 p.A81_K438del358 RefSeq GRCh38/hg38
XM_047420770.1 chr7:g.140739911_140794373del54463 c.241_1314del54463 p.Q81_P438del358 RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
XM_017012559 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140778042_140834720del56679 c.241_1314del56679 p.S81_P438del358 RefSeq GRCh38/hg38
XM_005250045 chr7:g.140783022_140834873del51852 c.242_1314+1del51852 p.A81_M438del358 RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140777028_140808995del31968 c.241_1314del31968 p.V81_A438del358 RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140783142_140834873del51732 c.241_1314del51732 p.A81_L438del358 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
BRAF A81_M438del gain of function - predicted