Gene Variant Detail

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Gene HRAS
Variant G12V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G12V does not lie within any known functional domains of the Hras protein (UniProt.org). G12V results in decreased Hras GTPase activity, loss of response to GTPase-activating proteins, leading to activation of downstream signaling pathways, and transformation of cultured cells (PMID: 24224811, PMID: 21850009, PMID: 6330729).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12V

HRAS mutant HRAS G12X HRAS G12V

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Transcript NM_005343.4
gDNA chr11:g.534288C>A
cDNA c.35G>T
Protein p.G12V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38
NM_176795 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38
NM_005343 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534288C>A c.35G>T p.G12V RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03190941 Phase Ib/II Cyclophosphamide anti-KRAS G12V mTCR cells Fludarabine Aldesleukin Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients Recruiting USA 0