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ALK F1174X - Gene Variant Detail

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Gene ALK
Variant F1174X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK F1174X indicates any Alk missense mutation that results in replacement of the phenylalanine (F) at amino acid 1174 by a different amino acid.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK F1174X

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Transcript NM_004304.5
gDNA chr2:g.29220829_29220831
cDNA c.3520_3522
Protein p.F1174
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220829_29220831 c.3520_3522 p.F1174 RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220829_29220831 c.3520_3522 p.F1174 RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK rearrange ALK F1174X lung non-small cell carcinoma predicted - sensitive Lorlatinib Clinical Study Actionable In a clinical study, treatment with Lorbrena (lorlatinib) resulted in antitumor activity in ALK-rearranged non-small cell lung cancer patients harboring ALK F1174X (n=12), with an objective response rate of 42% (5/12; 95% CI 15.0-72.0), a median duration of response not reached (NR), and a median progression-free survival of 7.4 months (95% CI 2.8-NR) (PMID: 30892989; NCT01970865). 30892989