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Gene CDK12
Variant del
Impact List deletion
Protein Effect loss of function
Gene Variant Descriptions CDK12 del indicates a deletion of the CDK12 gene.
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 del

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDK12 del prostate cancer sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) treatment inhibited viability of prostate cancer cell lines with biallelic CDK12 truncations in culture (PMID: 39321214). 39321214
CDK12 del prostate cancer sensitive Talazoparib Preclinical - Cell culture Actionable In a preclinical study, Talzenna (talazoparib) treatment inhibited viability of prostate cancer cell lines with biallelic CDK12 truncations in culture (PMID: 39321214). 39321214
CDK12 del prostate cancer sensitive Veliparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) treatment inhibited viability of a prostate cancer cell line with biallelic CDK12 truncations in culture (PMID: 39321214). 39321214
CDK12 del prostate cancer sensitive Rucaparib Preclinical - Cell line xenograft Actionable In a preclinical study, Rubraca (rucaparib) treatment inhibited viability of prostate cancer cell lines with biallelic CDK12 truncations in culture and inhibited tumor growth in a cell line xenograft model (PMID: 39321214). 39321214