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Gene FGFR2
Variant V565F
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 V565F (corresponds to V564F in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V565F results in increased Fgfr2 kinase activity in cell culture (PMID: 25169980) and has been shown to be associated with secondary resistance to FGFR inhibitors (PMID: 28034880, PMID: 31109923), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 V565F

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Transcript NM_001144913.1
gDNA chr10:g.121496705C>A
cDNA c.1693G>T
Protein p.V565F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
NM_001144913 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
XM_024447890.2 chr10:g.121488075_121488077delGTAinsTTT c.1693_1695delGTAinsTTT p.V565F RefSeq GRCh38/hg38
XM_024447890.1 chr10:g.121488075_121488077delGTAinsTTT c.1693_1695delGTAinsTTT p.V565F RefSeq GRCh38/hg38
NM_022970 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
XM_006717711 chr10:g.121488075_121488077delTACinsAAA c.1693_1695delGTAinsTTT p.V565F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 V565F Advanced Solid Tumor predicted - sensitive TYRA-200 Preclinical Actionable In a preclinical study, TYRA-200 inhibited FGFR2 V565F in an in vitro assay, demonstrated activity in cells expressing FGFR2 V565F in culture, and induced 64% tumor growth regression in an allograft model (Eur J Cancer 2022 Vol 174, Supp 1:S16). detail...