Therapy Detail
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| Therapy Name | TYRA-200 |
| Synonyms | |
| Therapy Description |
TYRA-200 is an FGFR1/2/3 inhibitor with activity against acquired resistance mutations, which potentially inhibits tumor growth (Eur J Cancer 2022 Vol 174, Supp 1:S16). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TYRA-200 | TYRA 200|TYRA200 | FGFR1 Inhibitor 28 FGFR2 Inhibitor 23 FGFR3 Inhibitor 19 | TYRA-200 is an FGFR1/2/3 inhibitor with activity against acquired resistance mutations, which potentially inhibits tumor growth (Eur J Cancer 2022 Vol 174, Supp 1:S16). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 N550H | Advanced Solid Tumor | predicted - sensitive | TYRA-200 | Preclinical - Biochemical | Actionable | In a preclinical study, TYRA-200 inhibited FGFR2 N550H in an in vitro assay (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
| FGFR2 V565L | Advanced Solid Tumor | predicted - sensitive | TYRA-200 | Preclinical - Biochemical | Actionable | In a preclinical study, TYRA-200 inhibited FGFR2 V565L in an in vitro assay (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
| FGFR2 N550K | endometrial cancer | predicted - sensitive | TYRA-200 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TYRA-200 demonstrated activity in an endometrial cancer cell line harboring FGFR2 N550K in culture and treatment resulted in 80% tumor regression in a cell line xenograft model (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
| FGFR2 K660N | Advanced Solid Tumor | predicted - sensitive | TYRA-200 | Preclinical - Cell culture | Actionable | In a preclinical study, TYRA-200 demonstrated activity in cells expressing FGFR2 K660N in culture (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
| FGFR2 N550K | Advanced Solid Tumor | predicted - sensitive | TYRA-200 | Preclinical - Cell culture | Actionable | In a preclinical study, TYRA-200 inhibited FGFR2 N550K in an in vitro assay and demonstrated activity in cells expressing FGFR2 N550K in culture (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
| FGFR2 V565F | Advanced Solid Tumor | predicted - sensitive | TYRA-200 | Preclinical | Actionable | In a preclinical study, TYRA-200 inhibited FGFR2 V565F in an in vitro assay, demonstrated activity in cells expressing FGFR2 V565F in culture, and induced 64% tumor growth regression in an allograft model (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
| FGFR2 E566A | Advanced Solid Tumor | predicted - sensitive | TYRA-200 | Preclinical - Biochemical | Actionable | In a preclinical study, TYRA-200 inhibited FGFR2 E566A in an in vitro assay (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
| FGFR2 V565I | Advanced Solid Tumor | predicted - sensitive | TYRA-200 | Preclinical - Cell culture | Actionable | In a preclinical study, TYRA-200 demonstrated activity in cells expressing FGFR2 V565I in culture (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
| FGFR2 K660E | Advanced Solid Tumor | predicted - sensitive | TYRA-200 | Preclinical - Cell culture | Actionable | In a preclinical study, TYRA-200 demonstrated activity in cells expressing FGFR2 K660E in culture (Eur J Cancer 2022 Vol 174, Supp 1:S16). | detail... |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06160752 | Phase I | TYRA-200 | Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations (SURF201) | Recruiting | USA | 0 |
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