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Gene FGFR2
Variant V565L
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 V565L (corresponds to V564L in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V565L has been shown to be associated with secondary resistance to FGFR inhibitors and demonstrates increased Fgfr2 kinase activity in cell culture (PMID: 25169980), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 V565L

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Transcript NM_001144913.1
gDNA chr10:g.121496705C>G
cDNA c.1693G>C
Protein p.V565L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913.1 chr10:g.121496705C>G c.1693G>C p.V565L RefSeq GRCh38/hg38
NM_001144913 chr10:g.121496705C>G c.1693G>C p.V565L RefSeq GRCh38/hg38
XM_024447890.2 chr10:g.121488077C>G c.1693G>C p.V565L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496705C>G c.1693G>C p.V565L RefSeq GRCh38/hg38
XM_006717711 chr10:g.121488077C>G c.1693G>C p.V565L RefSeq GRCh38/hg38
NM_022970 chr10:g.121496705C>G c.1693G>C p.V565L RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496705C>G c.1693G>C p.V565L RefSeq GRCh38/hg38
XM_024447890.1 chr10:g.121488077C>G c.1693G>C p.V565L RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121496705C>G c.1693G>C p.V565L RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 V565L Advanced Solid Tumor predicted - sensitive TYRA-200 Preclinical - Biochemical Actionable In a preclinical study, TYRA-200 inhibited FGFR2 V565L in an in vitro assay (Eur J Cancer 2022 Vol 174, Supp 1:S16). detail...