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Gene FGFR3
Variant G370C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR3 G370C lies within the juxtamembrane region of the Fgfr3 protein (PMID: 12009017). G370C confers a gain of function to the Fgfr3 protein as demonstrated by increased Fgfr3 phosphorylation, constitutive activation of the Mapk signaling pathway (PMID: 12009017), a growth advantage relative to wild-type Fgfr3 in a competition assay, and increased transformation activity in cultured cells (PMID: 34272467).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 act mut FGFR3 G370C

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Transcript NM_000142.5
gDNA chr4:g.1804362G>T
cDNA c.1108G>T
Protein p.G370C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354809.1 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
NM_000142 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
NM_001354810.2 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_006713873 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_011513420.1 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_011513420.2 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_006713872 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_011513422 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38
XM_011513420 chr4:g.1804362G>T c.1108G>T p.G370C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 G370C Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR3 G370C were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR3 G370C Advanced Solid Tumor predicted - resistant Dovitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR3 G370C were resistant to treatment with Dovitinib (TKI258) in culture (PMID: 34272467). 34272467
FGFR3 G370C transitional cell carcinoma sensitive Erdafitinib Guideline Actionable Balversa (erdafitinib) is included in guidelines for patients with advanced urothelial carcinoma who have received chemotherapy and an immune checkpoint inhibitor and harboring select FGFR mutations including FGFR3 G370C (PMID: 38490358; ESMO.org). 38490358 detail...
FGFR3 G370C transitional cell carcinoma sensitive Erdafitinib FDA approved - On Companion Diagnostic Actionable In a Phase II trial (BCL2001) that supported FDA approval, Balversa (erdafitinib) treatment resulted in an objective response rate of 40% (40/99, 3 complete response, 37 partial response) and a disease control rate of 80% in patients with metastatic or unresectable urothelial carcinoma harboring FGFR alterations and FGFR3 G370C is included in the companion diagnostic (PMID: 31340094; NCT02365597). detail... 31340094 detail...
FGFR3 G370C transitional cell carcinoma sensitive Erdafitinib Case Reports/Case Series Actionable In a Phase III trial (THOR), Balversa (erdafitinib) treatment led to improved median overall survival (25.4 mo vs. 12.4 mo), median progression-free survival (8.4 mo vs. 2.9 mo), objective response rate (57.1% vs. 15.4%), and disease control rate (92.9% vs. 76.9%) compared to chemotherapy in Japanese patients with metastatic urothelial carcinoma with alterations in FGFR2 or FGFR3 (n=14), including FGFR3 Y373C (n=3), S249C (n=4), G370C (n=2), R248C (n=2), and FGFR3-TACC3 (n=3) (PMID: 39017806; NCT03390504). 39017806
FGFR3 G370C bladder urothelial carcinoma sensitive Erdafitinib Guideline Actionable Balversa (erdafitinib) is included in guidelines for patients with advanced bladder urothelial carcinoma who have received chemotherapy and an immune checkpoint inhibitor and harboring select FGFR mutations including FGFR3 G370C (PMID: 38490358; ESMO.org). 38490358 detail...
FGFR3 G370C bladder urothelial carcinoma sensitive Erdafitinib FDA approved - On Companion Diagnostic Actionable In a Phase II trial (BCL2001) that supported FDA approval, Balversa (erdafitinib) treatment resulted in an objective response rate of 40% (40/99, 3 complete response, 37 partial response) and a disease control rate of 80% in patients with metastatic or unresectable urothelial carcinoma harboring FGFR alterations and FGFR3 G370C is included in the companion diagnostic (PMID: 31340094; NCT02365597). detail... 31340094 detail...
FGFR3 G370C urinary bladder cancer predicted - sensitive Erdafitinib Case Reports/Case Series Actionable In a Phase II trial (THOR-2), Balversa (erdafitinib) improved median recurrence-free survival (not reached vs 11.6 mo, HR=0.28, p=0.0008) in patients with recurrent high risk non-muscle invasive bladder cancer harboring FGFR3 mutations such as S249C (n=31), R248C (n=4), G370C, (n=3) or Y373C (n=10) or FGFR2-BICC1 (n=1), FGFR3-BAIAP2L1 (n=1), or FGFR3-TACC3 (n=5) compared to intravesical chemotherapy (PMID: 37871701; NCT04172675). 37871701
FGFR3 G370C Advanced Solid Tumor predicted - resistant E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR3 G370C were resistant to treatment with E7090 in culture (PMID: 34272467). 34272467