AXL amp
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Gene AXL
Variant amp
Impact List none
Protein Effect no effect
Gene Variant Descriptions AXL amp indicates an increased number of copies of the AXL gene. However, the mechanism causing the increase is unspecified.
Associated Drug Resistance
Category Variants Paths

AXL amp

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AXL amp lung non-small cell carcinoma predicted - sensitive Glesatinib Phase I Actionable In a Phase I trial, a patient with non-small cell lung carcinoma harboring AXL amplification was sensitive to treatment with Glesatinib (MGCD265), demonstrating a 50% decrease in lesion size (PMID: 26555154). 26555154
AXL amp lung non-small cell carcinoma predicted - sensitive Glesatinib Case Reports/Case Series Actionable In a Phase I trial, Glesatinib (MGCD265) treatment resulted in partial responses (PR) as the best response in 9 of 49 evaluable patients with advanced solid tumors harboring MET or AXL alterations, including a PR lasting 3.5 years in a patient with AXL-amplified (CN 13) non-small cell lung cancer (PMID: 36459255; NCT00697632). 36459255