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Gene | NTRK2 |
Variant | L568V |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | NTRK2 L568V lies within the protein kinase domain of the Ntrk2 protein (UniProt.org). L568V is predicted to have no effect on Ntrk2 protein function, as the corresponding variant in an alternative isoform (L584V) demonstrates similar transformation ability and levels of autophosphorylation to wild-type Ntrk2 in cell culture (PMID: 30926633). |
Associated Drug Resistance | |
Category Variants Paths |
NTRK2 mutant NTRK2 L568V |
Transcript | NM_001018064.3 |
gDNA | chr9:g.84934278T>G |
cDNA | c.1702T>G |
Protein | p.L568V |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |