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Gene PIK3CA
Variant P539R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA P539R lies within the PIK helical domain of the Pik3ca protein (UniProt.org). P539R increases the stability of the Pik3ca protein, confers a gain of function, as indicated by constitutive phosphorylation of downstream targets Akt and S6, and is transforming in cell culture (PMID: 18951408, PMID: 17376864, PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA P539R

PIK3CA mutant PIK3CA exon10 PIK3CA P539R

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Transcript NM_006218.4
gDNA chr3:g.179218286C>G
cDNA c.1616C>G
Protein p.P539R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
NM_006218 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218286C>G c.1616C>G p.P539R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA P539R breast cancer sensitive BAY1125976 Preclinical - Cell culture Actionable In a preclinical study, BAY1125976 inhibited proliferation of a breast cancer cell line harboring PIK3CA P539R in culture (PMID: 27699769). 27699769
PIK3CA P539R breast cancer predicted - sensitive CYH33 Preclinical - Cell culture Actionable In a preclinical study, CYH33 inhibited proliferation of a breast cancer cell line harboring PIK3CA P539R in culture (PMID: 30003928). 30003928