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Therapy Name	CYH33
Synonyms
Therapy Description	CCYH33 is a PIK3CA inhibitor that suppresses the activation of Pi3k/Akt/Mtor signaling, which potentially induces cell cycle arrest and inhibits tumor growth (PMID: 30003928).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
CYH33		CYH-33\|CYH 33\|HH-CYH33\|HHCYH 33	PIK3CA inhibitor 27	CCYH33 is a PIK3CA inhibitor that suppresses the activation of Pi3k/Akt/Mtor signaling, which potentially induces cell cycle arrest and inhibits tumor growth (PMID: 30003928).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PIK3CA H1047R	breast cancer	sensitive	CYH33	Preclinical - Cell line xenograft	Actionable	In a preclinical study, CYH33 inhibited proliferation of breast cancer cell lines harboring PIK3CA H1047R in culture, inhibited tumor progression in a transgenic mouse model, and induced cell cycle arrest, and inhibited PI3K signaling and tumor growth in cell line xenograft models (PMID: 30003928).	30003928
PIK3CA E542K PTEN loss	breast cancer	predicted - sensitive	CYH33	Preclinical - Cell culture	Actionable	In a preclinical study, CYH33 inhibited proliferation of a breast cancer cell line harboring PIK3CA E542K and PTEN loss in culture (PMID: 30003928).	30003928
PIK3CA E545K	breast cancer	predicted - sensitive	CYH33	Preclinical - Cell culture	Actionable	In a preclinical study, CYH33 inhibited proliferation of a breast cancer cell line harboring PIK3CA E545K in culture (PMID: 30003928).	30003928
PIK3CA H1047R PTEN loss	breast cancer	predicted - sensitive	CYH33	Preclinical - Cell culture	Actionable	In a preclinical study, CYH33 inhibited proliferation of a breast cancer cell line harboring PIK3CA H1047R and PTEN loss in culture (PMID: 30003928).	30003928
PIK3CA mutant	breast cancer	predicted - sensitive	CYH33	Preclinical - Cell culture	Actionable	In a preclinical study, breast cancer cell lines harboring PIK3CA mutations demonstrated increased sensitivity to CYH33 compared to cell lines with wild-type PIK3CA in culture (p<0.01) (PMID: 30003928).	30003928
PIK3CA P539R	breast cancer	predicted - sensitive	CYH33	Preclinical - Cell culture	Actionable	In a preclinical study, CYH33 inhibited proliferation of a breast cancer cell line harboring PIK3CA P539R in culture (PMID: 30003928).	30003928
PTEN loss	breast cancer	no benefit	CYH33	Preclinical - Cell culture	Actionable	In a preclinical study, PTEN loss was not associated with sensitivity to CYH33 in breast cancer cell lines in culture (PMID: 30003928).	30003928

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