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Gene BRAF
Variant A598_T599insV
Impact List insertion
Protein Effect gain of function
Gene Variant Descriptions BRAF A598_T599insV results in the insertion of a valine (V) in the protein kinase domain of the Braf protein between amino acids 598 and 599 (UniProt.org). A598_T599insV results in increased Braf kinase activity, increased downstream Mapk and Mek signaling, and the ability to transform cells in culture (PMID: 16501605).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF A598_T599insV

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Transcript NM_004333.6
gDNA chr7:g.140753340_140753341insTAC
cDNA c.1794_1795insGTA
Protein p.A598_T599insV
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.6 chr7:g.140753340_140753341insTAC c.1794_1795insGTA p.A598_T599insV RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753340_140753341insTAC c.1794_1795insGTA p.A598_T599insV RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753340_140753341insTAC c.1794_1795insGTA p.A598_T599insV RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753340_140753341insTAC c.1794_1795insGTA p.A598_T599insV RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753340_140753341insTAC c.1794_1795insGTA p.A598_T599insV RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753340_140753341insTAC c.1794_1795insGTA p.A598_T599insV RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753340_140753341insTAC c.1794_1795insGTA p.A598_T599insV RefSeq GRCh38/hg38
NM_004333 chr7:g.140753340_140753341insTAC c.1794_1795insGTA p.A598_T599insV RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries