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Gene APC
Variant L852*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC L852* results in a premature truncation of the Apc protein at amino acid 852 of 2843 (UniProt.org). L852* has not been characterized, however, due to the effects of other truncation mutations downstream of L852 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC L852*

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Transcript NM_000038.6
gDNA chr5:g.112838149T>A
cDNA c.2555T>A
Protein p.L852*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.2 chr5:g.112838149T>A c.2555T>A p.L852* RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838149T>A c.2555T>A p.L852* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838149T>A c.2555T>A p.L852* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112838149T>A c.2555T>A p.L852* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838149T>A c.2555T>A p.L852* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838149T>A c.2555T>A p.L852* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838149T>A c.2555T>A p.L852* RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC L852* colorectal cancer predicted - resistant G007-LK Preclinical Actionable In a preclinical study, G007-LK treatment did not alter gene expression pattern or affect growth in intestinal organoids established from mouse models of colorectal cancer driven by APC L850* (corresponding to L852* in human), and had no effect on tumor cell growth and differentiation in APC L850* mouse models (PMID: 31337618). 31337618