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| Profile Name | APC L852* |
| Gene Variant Detail | |
| Relevant Treatment Approaches | CTNNB1 Inhibitor Tankyrase Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| APC L852* | colorectal cancer | predicted - resistant | Tankyrase Inhibitor | G007-LK | Preclinical | Actionable | In a preclinical study, G007-LK treatment did not alter gene expression pattern or affect growth in intestinal organoids established from mouse models of colorectal cancer driven by APC L850* (corresponding to L852* in human), and had no effect on tumor cell growth and differentiation in APC L850* mouse models (PMID: 31337618). | 31337618 |