BRAF A598V
Gene Variant Detail

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Gene BRAF
Variant A598V
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF A598V lies within the protein kinase domain of the Braf protein (UniProt.org). A598V is associated with increased activation of Braf and downstream Mek and Erk in tumor samples (PMID: 19200582), and therefore, is predicted to lead to a gain of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF A598X BRAF A598V

BRAF mutant BRAF act mut BRAF A598V

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Transcript NM_004333.6
gDNA chr7:g.140753342G>A
cDNA c.1793C>T
Protein p.A598V
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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