ALK F1174C
Gene Variant Detail

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Gene ALK
Variant F1174C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK F1174C lies within the protein kinase domain of the Alk protein (UniProt.org). F1174C confers a gain of function to Alk, as indicated by constitutive Alk phosphorylation (PMID: 24509625), and increased cell viability in culture (PMID: 29559559).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK F1174C

ALK mutant ALK F1174X ALK F1174C

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Transcript NM_004304.5
gDNA chr2:g.29220830A>C
cDNA c.3521T>G
Protein p.F1174C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220830A>C c.3521T>G p.F1174C RefSeq GRCh38/hg38
NM_004304 chr2:g.29220830A>C c.3521T>G p.F1174C RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220830A>C c.3521T>G p.F1174C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK F1174C gain of function ALK Inhibitor
EML4 - ALK ALK F1174C Brigatinib Lorlatinib
EML4 - ALK ALK F1174C ALK L1198F Crizotinib
EML4 - ALK ALK F1174C ALK D1203N
EML4 - ALK ALK C1156Y ALK F1174C
EML4 - ALK ALK F1174C ALK L1196M
EML4 - ALK ALK F1174C ALK G1269A
ALK rearrange ALK F1174C
ALK rearrange ALK F1174C ALK G1202R
EML4 - ALK ALK F1174C ALK E1210K
EML4 - ALK ALK E1129V ALK I1171T ALK F1174C ALK F1174L ALK F1174V ALK G1269A
EML4 - ALK ALK F1174C ALK G1202R
ALK F1174C TP53 wild-type
EML4 - ALK ALK F1174C ALK V1180L