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Gene ALK
Variant F1174I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK F1174I lies within the protein kinase domain of the Alk protein (UniProt.org). F1174I results in ligand-independent phosphorylation of the Alk protein, activation of Erk, Stat3 pathways, and is transforming in cell culture (PMID: 23104988).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK F1174I

ALK mutant ALK F1174X ALK F1174I

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Transcript NM_004304.5
gDNA chr2:g.29220831A>T
cDNA c.3520T>A
Protein p.F1174I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220831A>T c.3520T>A p.F1174I RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220831A>T c.3520T>A p.F1174I RefSeq GRCh38/hg38
NM_004304 chr2:g.29220831A>T c.3520T>A p.F1174I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK F1174I Advanced Solid Tumor sensitive Lorlatinib Preclinical - Cell culture Actionable In a preclinical study, Lorbrena (lorlatinib) treatment inhibited Alk phosphorylation and viability in transformed cells expressing ALK F1174I in culture (PMID: 27483357). 27483357