Gene Variant Detail

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Gene BRAF
Variant G606E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G606E lies within the protein kinase domain of the Braf protein (UniProt.org). G606E has been identified in sequencing studies (PMID: 29320312, PMID: 28936923, PMID: 15331929), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF G606E

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Transcript NM_004333.6
gDNA chr7:g.140753318C>T
cDNA c.1817G>A
Protein p.G606E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140753318C>T c.1817G>A p.G606E RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753318C>T c.1817G>A p.G606E RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753318C>T c.1817G>A p.G606E RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140749351C>T c.1817G>A p.G606E RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753318C>T c.1817G>A p.G606E RefSeq GRCh38/hg38
NM_004333 chr7:g.140753318C>T c.1817G>A p.G606E RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753318C>T c.1817G>A p.G606E RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753318C>T c.1817G>A p.G606E RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753318C>T c.1817G>A p.G606E RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries