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Gene BRAF
Variant H608R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF H608R lies within the protein kinase domain of the Braf protein (UniProt.org). H608R has been identified in sequencing studies (PMID: 15331929, PMID: 37465126), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF H608R

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Transcript NM_004333.6
gDNA chr7:g.140753312T>C
cDNA c.1823A>G
Protein p.H608R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001374258.1 chr7:g.140754225T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753312T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753312T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140754225T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753312T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753312T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
XM_017012558 chr7:g.140754225T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
NM_004333 chr7:g.140753312T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753312T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140754225T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753312T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140754225T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
XM_017012559 chr7:g.140754225T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140754225T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753312T>C c.1823A>G p.H608R RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140754225T>C c.1823A>G p.H608R RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References