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Gene BRAF
Variant P453T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF P453T does not lie within any known functional domains of the Braf protein (UniProt.org). P453T has been identified in sequencing studies (PMID: 27717198, PMID: 16404419), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF P453T

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Transcript NM_004333.6
gDNA chr7:g.140781651G>T
cDNA c.1357C>A
Protein p.P453T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047420769.1 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
NM_004333 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140778040G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140781651G>T c.1357C>A p.P453T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
BRAF P453T unknown