Gene Variant Detail

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Gene BRAF
Variant R603*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions BRAF R603* results in a premature truncation of the Braf protein at amino acid 603 of 766 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), R603* is predicted to lead to a loss of Braf function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF inact mut BRAF R603*

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Transcript NM_004333.6
gDNA chr7:g.140753328G>A
cDNA c.1807C>T
Protein p.R603*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140753328G>A c.1807C>T p.R603* RefSeq GRCh38/hg38
NM_004333 chr7:g.140753328G>A c.1807C>T p.R603* RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753328G>A c.1807C>T p.R603* RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753328G>A c.1807C>T p.R603* RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753328G>A c.1807C>T p.R603* RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753328G>A c.1807C>T p.R603* RefSeq GRCh38/hg38
NM_001378475.1 chr7:g.140739868T>A c.1807A>T p.R603* RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753328G>A c.1807C>T p.R603* RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753328G>A c.1807C>T p.R603* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
BRAF R603* loss of function - predicted