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Gene BRAF
Variant S605F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF S605F lies within the protein kinase domain of the Braf protein (UniProt.org). S605F has been identified in sequencing studies (PMID: 15331929), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF S605F

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Transcript NM_004333.6
gDNA chr7:g.140753321_140753322delAGinsTT
cDNA c.1813_1814delAGinsTT
Protein p.S605F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378472.1 chr7:g.140749308_140749309delCAinsTT c.1814_1815delCAinsTT p.S605F RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140749308_140749309delCAinsTT c.1814_1815delCAinsTT p.S605F RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753321_140753322delAGinsTT c.1813_1814delAGinsTT p.S605F RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753321_140753322delAGinsTT c.1813_1814delAGinsTT p.S605F RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753321_140753322delCTinsAA c.1813_1814delAGinsTT p.S605F RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753321_140753322delAGinsTT c.1813_1814delAGinsTT p.S605F RefSeq GRCh38/hg38
NM_004333 chr7:g.140753321_140753322delCTinsAA c.1813_1814delAGinsTT p.S605F RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753321_140753322delAGinsTT c.1813_1814delAGinsTT p.S605F RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140753330G>A c.1814C>T p.S605F RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753321_140753322delAGinsTT c.1813_1814delAGinsTT p.S605F RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753321_140753322delAGinsTT c.1813_1814delAGinsTT p.S605F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References