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Gene ABL1
Variant T315M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ABL1 T315M lies within the protein kinase domain of the Abl1 protein (UniProt.org). T315M is associated with Abl1 inhibitor resistance in the context of BCR-ABL1 (PMID: 26511402, PMID: 31543464) and demonstrates catalytic efficiency (kcat/km) similar to wild-type Abl1 in an in vitro assay (PMID: 30684523), but has not been fully biochemically characterized and therefore, its effect on Abl1 protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

ABL1 mutant ABL1 T315M

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Transcript NM_005157.6
gDNA chr9:g.130872896_130872897delCTinsTG
cDNA c.944_945delCTinsTG
Protein p.T315M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005157 chr9:g.130872896_130872897delCTinsTG c.944_945delCTinsTG p.T315M RefSeq GRCh38/hg38
NM_005157.5 chr9:g.130872896_130872897delCTinsTG c.944_945delCTinsTG p.T315M RefSeq GRCh38/hg38
NM_005157.6 chr9:g.130872896_130872897delCTinsTG c.944_945delCTinsTG p.T315M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries