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Gene BRAF
Variant S605N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF S605N lies within the protein kinase domain of the Braf protein (UniProt.org). S605N has been identified in sequencing studies (PMID: 29176861, PMID: 28628916, PMID: 15331929), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF S605N

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Transcript NM_004333.6
gDNA chr7:g.140753321C>T
cDNA c.1814G>A
Protein p.S605N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753321C>T c.1814G>A p.S605N RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753321C>T c.1814G>A p.S605N RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753321C>T c.1814G>A p.S605N RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753321C>T c.1814G>A p.S605N RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753321C>T c.1814G>A p.S605N RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140749308_140749310delTCAinsAAC c.1813_1815delTCAinsAAC p.S605N RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140753330_140753331delTCinsAA c.1813_1814delTCinsAA p.S605N RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753321C>T c.1814G>A p.S605N RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753321C>T c.1814G>A p.S605N RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140749308_140749310delTCAinsAAC c.1813_1815delTCAinsAAC p.S605N RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753321C>T c.1814G>A p.S605N RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Protein Effect Treatment Approaches
BRAF S605N unknown