Gene Variant Detail

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Gene BRAF
Variant V471F
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions BRAF V471F lies within the protein kinase domain of the Braf protein (UniProt.org). V471F results in a loss of Braf kinase activity, however, results in dimerization-dependent activation of Erk signaling and is weakly transforming in cultured cells (PMID: 25348715).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF inact mut BRAF V471F

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Transcript NM_004333.6
gDNA chr7:g.140781597C>A
cDNA c.1411G>T
Protein p.V471F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.2 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38
XM_005250045 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38
NM_004333 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781597C>A c.1411G>T p.V471F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References