BRAF V600L
Gene Variant Detail

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Gene BRAF
Variant V600L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF V600L (previously reported as V599L) lies within the activation segment of the protein kinase domain of the Braf protein (PMID: 15035987). V600L results in increased cell proliferation and cell viability compared to wild-type Braf in one of two cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF V600X BRAF V600L

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Transcript NM_004333.6
gDNA chr7:g.140753337C>G
cDNA c.1798G>C
Protein p.V600L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333 chr7:g.140753337C>G c.1798G>C p.V600L RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753337C>G c.1798G>C p.V600L RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753337C>G c.1798G>C p.V600L RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753337C>G c.1798G>C p.V600L RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753337C>G c.1798G>C p.V600L RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753337C>G c.1798G>C p.V600L RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753337C>G c.1798G>C p.V600L RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753337C>G c.1798G>C p.V600L RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries