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Gene BRAF
Variant T310I
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF T310I does not lie within any known functional domains of the Braf protein (UniProt.org). T310I is predicted to lead to a gain of Braf protein function as indicated by intermediate increase of Erk phosphorylation in culture, and is associated with resistance to Raf inhibitors (PMID: 31158244).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF act mut BRAF T310I

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Transcript NM_004333.6
gDNA chr7:g.140800413G>A
cDNA c.929C>T
Protein p.T310I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378469.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_004333 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012559.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012559 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_005250045 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
XM_017012558 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140800413G>A c.929C>T p.T310I RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries