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Gene RET
Variant S409Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET S409Y lies within the extracellular domain of the Ret protein (UniProt.org). S409Y results in increased phosphorylation of Akt and Erk, and promotes colony formation in cell culture (PMID: 31364476).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET S409Y

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Transcript NM_020975.6
gDNA chr10:g.43109193C>A
cDNA c.1226C>A
Protein p.S409Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020630 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References