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Gene RET
Variant S409Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET S409Y lies within the extracellular domain of the Ret protein (UniProt.org). S409Y results in increased phosphorylation of Akt and Erk, and promotes colony formation in cell culture (PMID: 31364476).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET S409Y

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Transcript NM_020975.6
gDNA chr10:g.43109193C>A
cDNA c.1226C>A
Protein p.S409Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020630 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43109193C>A c.1226C>A p.S409Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
RET S409Y gain of function RET Inhibitor