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Gene RET
Variant M918T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET M918T lies within the protein kinase domain of the Ret protein (Uniprot.org). M918T results in ligand-independent autophosphorylation of Ret and increased substrate binding, is transforming (PMID: 17108110), and confers drug resistance in the context of KIF5B-RET in culture (PMID: 29908090).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET act mut RET M918T

RET mutant RET M918X RET M918T

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Transcript NM_020975.6
gDNA chr10:g.43121968T>C
cDNA c.2753T>C
Protein p.M918T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_020630 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43128115T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_020975 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43121968T>C c.2753T>C p.M918T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries