RET L881V
Gene Variant Detail

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Gene RET
Variant L881V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET L881V lies within the protein kinase domain of the Ret protein (UniProt.org). L881V has been demonstrated to confer resistance to some RET inhibitors in the context of KIF5B-RET in cultured cells (PMID: 31118272), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET L881V

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Transcript NM_020975.6
gDNA chr10:g.43120114C>G
cDNA c.2641C>G
Protein p.L881V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_020630 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_001406771.1 chr10:g.43126614C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_001406773.1 chr10:g.43126614C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_020975 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120114C>G c.2641C>G p.L881V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
RET L881V unknown
RET V804M RET G810S RET L881V RET M918T