TP53 Y220S
Gene Variant Detail

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Gene TP53
Variant Y220S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 Y220S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). Y220S is predicted to result in decreased Tp53 stability based on structural modeling (PMID: 31128451), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jun 2026).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 Y220S

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Transcript NM_000546.6
gDNA chr17:g.7674872T>G
cDNA c.659A>C
Protein p.Y220S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407270.1 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_000546 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674872T>G c.659A>C p.Y220S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y220S Advanced Solid Tumor decreased response Rezatapopt Preclinical - Cell culture Actionable In a preclinical study, Rezatapopt (PC14586) reactivated Tp53 function, inhibited proliferation, viability and colony formation, and induced cell cycle arrest and apoptosis in cells expressing TP53 Y220S with reduced potency compared to TP53 Y220C in culture (PMID: 41748563). 41748563