Molecular Profile Detail

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Profile Name TP53 Y220S
Gene Variant Detail

TP53 Y220S (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y220S Advanced Solid Tumor decreased response Rezatapopt Preclinical - Cell culture Actionable In a preclinical study, Rezatapopt (PC14586) reactivated Tp53 function, inhibited proliferation, viability and colony formation, and induced cell cycle arrest and apoptosis in cells expressing TP53 Y220S with reduced potency compared to TP53 Y220C in culture (PMID: 41748563). 41748563