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Gene RET
Variant R886W
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET R886W lies within the protein kinase domain of the Ret protein (UniProt.org). R886W confers a gain of function to the Ret protein as demonstrated by increased Erk1/2, Stat1/3, and Tcf activation and transformation of cultured cells (PMID: 21551259).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET R886W

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Transcript NM_020975.6
gDNA chr10:g.43120129C>T
cDNA c.2656C>T
Protein p.R886W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020630.7 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_020630 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43124887_43124889delCGCinsTGG c.2656_2658delCGCinsTGG p.R886W RefSeq GRCh38/hg38
NM_001406766.1 chr10:g.43124887_43124889delCGCinsTGG c.2656_2658delCGCinsTGG p.R886W RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_020975 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43124887_43124889delCGCinsTGG c.2656_2658delCGCinsTGG p.R886W RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET R886W Advanced Solid Tumor sensitive Sorafenib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing RET R886W were sensitive to treatment with Nexavar (sorafenib) in culture, demonstrating reduced cell proliferation (PMID: 21551259). 21551259