We’re improving your experience!

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

RET R886W - Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RET
Variant R886W
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET R886W lies within the protein kinase domain of the Ret protein (UniProt.org). R886W confers a gain of function to the Ret protein as demonstrated by increased Erk1/2, Stat1/3, and Tcf activation and transformation of cultured cells (PMID: 21551259).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET R886W

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_020975.6
gDNA chr10:g.43120129C>T
cDNA c.2656C>T
Protein p.R886W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406766.1 chr10:g.43124887_43124889delCGCinsTGG c.2656_2658delCGCinsTGG p.R886W RefSeq GRCh38/hg38
NM_020975 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406770.1 chr10:g.43124887_43124889delCGCinsTGG c.2656_2658delCGCinsTGG p.R886W RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406767.1 chr10:g.43124887_43124889delCGCinsTGG c.2656_2658delCGCinsTGG p.R886W RefSeq GRCh38/hg38
NM_020630 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120129C>T c.2656C>T p.R886W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET R886W Advanced Solid Tumor sensitive Sorafenib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing RET R886W were sensitive to treatment with Nexavar (sorafenib) in culture, demonstrating reduced cell proliferation (PMID: 21551259). 21551259