BRIP1 R777C
Gene Variant Detail

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Gene BRIP1
Variant R777C
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions BRIP1 R777C does not lie within any known functional domains of the Brip1 protein (UniProt.org). R777C demonstrates reduced protein stability and fails to rescue mitomycin-induced DNA cross-linking damage in cell culture (PMID: 31822495), and therefore, is predicted to lead to a loss of Brip1 protein function.
Associated Drug Resistance
Category Variants Paths

BRIP1 mutant BRIP1 inact mut BRIP1 R777C

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Transcript NM_032043.3
gDNA chr17:g.61743063G>A
cDNA c.2329C>T
Protein p.R777C
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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